Abstract
s A.I.S.F. Annual Meeting (Rome, February 25th−26th, 2010) / Digestive and Liver Disease 42 Suppl. 1 (2010) S1–S51 S5 patients with SSM lower or equal 75 kPa (12.5mmHg vs 19.1mmHg, p = 0.013) without significant differences for bilirubin, albumin or INR values (p = ns). All 9 patients with SSM=75 kPa had large esophageal varices (6 F2, 3 F3). In the whole cohort of patients, 80 (55.6%) had EV and 28 (19.4%) had large EV (F2 or F3). The AUROCs of LS and SS were almost the same (0.76 vs 0.73) for the prediction of EV but SSM was significantly better than LSM to predict large EV (AUROCs: 0.84 vs 0.72). The best cut-offs of LS and SS for the diagnosis of cirrhosis with EV were 21 kPa (Sens. 71%, Spec. 72%) and 47 kPa (Sens. 79%, Spec. 70%) respectively. Twenty-four patients with a LSM 13Kpa, in accordance to the literature (Friedrich-Rust, Gastroenterology 2008). VT provided sensitivity and specificity for the diagnosis of cirrhosis (Fibroscan reference) of respectively 93% and 84.4% at a cut-off of 1.75m/s with an AUROC of 0.950. This threshold was validated in the 70 patients with histologically proven cirrhosis, producing a sensitivity of 82% and a specificity of 89%, with an AUROC of 0.912. A strict correlation was observed between liver stiffness values obtained with Fibroscan and VT, either in all 115 subjects (r = 0.879, p< 0.0001) or only in the 90 patients with chronic liver disease (r = 0.857, p< 0.0001). Conclusions: Virtual Touch modality, appears to be a very promising tool in the evaluation of liver stiffness, with results similar to Fibroscan, but with the advantage of being integrated in ultrasound equipments. 12 A REDUCED REGULATORY ACTIVITY AND PREDOMINANCE OF THE GAMMA-DELTA VDELTA1 SUBSET CHARACTERISE PATIENTS WITH HCV-RELATED TYPE 2 CRYOGLOBULINEMIA S. Ferri1, R. Menichella1, C. Lalanne1, C. Quarneti1, M. Bassi2, P. Muratori1, F.B. Bianchi1, L. Muratori1, M. Lenzi1. Department of Clinical Medicine, University of Bologna, Bologna, Italy; Department of Clinical Pathology, S. Orsola-Malpighi Hospital,
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