Abstract
The availability of standardized extracts makes it possible to perform rush immunotherapy (RT) without major risks. Mites are the most prevalent allerqen in Europe. RT in mite allergy was therefore started. RT was aiven to 100 patients ranqinq in aqe from 3 to 41 years (18+i4 years). The same lyephilised standardized extract of Dermatophagoides pteronyssinus was used for all tests and treatments. The maintenance dose (1,500 BU or 0.1 ml of l/100 extract) was reached in 3 to 6 days according to side reactions. Systemic reactions occurred in 12% of patients over a dose of 150 BU. They were never severe. RT was evaluated by serial quantitative prick tests with mite and unrelated allergens, specific IgE (RAST) and IgG (protein A technique) and total IgE in all patients at days 0, 7, 42 and 6 and 12 months. Bronchial challenges on days 0 and 42 were performed in 20 adults or adolescents by total body plethysmography. A sianificant decrease in skin test reactivity (p<O.OOi) was observed after 7 days for mites but not for unrelated allergens or positive controls. This decreased reactivity continued through out the study. A significant (p<O.O05) increase of the threshold dose inducing a positive bronchial challenae was seen. Soecific ICIE did not increase significantly. Specific IgGincreased significantly but the decreased reactivity in skin test could not be related to the raise in specific IgG.
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