Abstract
For diagnosing a majority of breast lesions, a high-quality hematoxylin-eosin (H&E) stained section is all that is needed. However, in our quest for improved diagnostic accuracy, immunohistochemistry (IHC) is frequently used in diagnostic breast pathology. The sheer volume and genuine difficulty of some cases, even for breast experts, result in frequent use of IHC in day-to-day practice. This chapter addresses diagnostic issues involving stromal invasion, papillary lesions, atypical proliferative lesions, discrimination of ductal and lobular neoplasia, and identification of other breast tumor types, Paget’s disease of the breast, metastatic breast carcinomas, and fibroepithelial lesions. The prognostic and predictive markers in breast carcinomas are discussed in a separate chapter.
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