Abstract
Introduction: Docosahexaenoic acid (22:6n3; DHA), an essential fatty acid (EFA), is a major component of the nervous system and is required for optimal neuronal function. Human infants can synthesize DHA from dietary alpha-linolenic acid (18:3n3;LNA) with eicosapentaenoate (20:5n3; EPA) and docosapentaenoate (22:5n3; DPA) as intermediates. It is of interest then to determine whether LNA or its partially metabolized form, EPA, would be a better substrate to support DHA biosynthesis. Previously we have used isotopic ratios to report a higher DHA formation from LNA(x5) compared to EPA.
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