11 A 5 year study of infective endocarditis managed by a multidisciplinary team in a regional cardiothoracic centre: trends in referral, infective organisms and outcomes

Abstract

Introduction Infective endocarditis (IE) is associated with a protracted inpatient stay, prolonged intravenous antimicrobial therapy and significant morbidity and mortality. Methods All patients with a diagnosis of IE at the Sussex Cardiac Centre (SCC) between 2016 and 2020 were included. Demographics, clinical characteristics, management, complications and outcomes were analysed. Logistic EuroSCORE, EuroSCORE II and Risk-E Scores were calculated for patients undergoing operative management. Results In the 5-year period 202 patients had 209 diagnoses of IE. Seven patients had recurrent IE; 3 with the same organism but with persistent risk factors after initial treatment (Intravenous drug users [IVDUs] n = 2 and colonic polyps n=1). IE cases increased yearly by approximately 4 cases per year (p Conclusions There has been an increase in IE cases managed at the SCC over the last 5 years, with more transfers from other hospitals. This could be due to an increase in absolute IE numbers as well as better awareness of the need for early surgery and the involvement of an IE MDT. We report a previously unidentified male predominance in IE across all major organisms and a significant increase in oral streptococci infection; both require further exploration. In this population the Risk-E Score tended to overestimate in-hospital mortality. Larger multi-centre studies are required to explore these trends in sub-grouped populations. Conflict of Interest None