Progress in Neuro-Psychopharmacology and Biological Psychiatry | VOL. 24

10μG CCK-4 premedication and 35% CO2 challenge in healthy volunteers

Publication Date Apr 1, 2000


1. The purpose of the study was to confirm whether a subthreshold dose of CCK-4 would enhance the vulnerability of healthy subjects to a 35% carbon dioxide challenge. 2. 40 subjects, with no prior or present psychiatric disorder and in good physical health were challenged with a vital capacity breath of a 35% carbon dioxide 65% oxygen mixture, immediately after an intravenous injection of 10 microg CCK-4 or placebo, according to a random order, double blind, separate group design. 3. Subjects reported significantly less anxiety and panic symptoms upon carbon dioxide after premedication with CCK-4 than after placebo. 4. CCK-4 and carbon dioxide seem to inhibit rather than enhance each other's effects, possibly through an effect on different neurobiological systems.

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Carbon Dioxide Challenge
Good Physical Health
Carbon Dioxide
CO2 Challenge
Panic Symptoms
Neurobiological Systems
Oxygen Mixture
Prior Psychiatric Disorder
Challenge In Volunteers
Healthy Volunteers

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