Progress in Neuro-Psychopharmacology and Biological Psychiatry | VOL. 24

10μG CCK-4 premedication and 35% CO2 challenge in healthy volunteers

Publication Date Apr 1, 2000


1. The purpose of the study was to confirm whether a subthreshold dose of CCK-4 would enhance the vulnerability of healthy subjects to a 35% carbon dioxide challenge. 2. 40 subjects, with no prior or present psychiatric disorder and in good physical health were challenged with a vital capacity breath of a 35% carbon dioxide 65% oxygen mixture, immediately after an intravenous injection of 10 microg CCK-4 or placebo, according to a random order, double blind, separate group design. 3. Subjects reported significantly less anxiety and panic symptoms upon carbon dioxide after premedication with CCK-4 than after placebo. 4. CCK-4 and carbon dioxide seem to inhibit rather than enhance each other's effects, possibly through an effect on different neurobiological systems.


Carbon Dioxide Challenge Good Physical Health Carbon Dioxide CO2 Challenge Panic Symptoms Neurobiological Systems Oxygen Mixture Prior Psychiatric Disorder Challenge In Volunteers Healthy Volunteers

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