1099 ANALYSIS OF RISK FACTORS FOR BIOCHEMICAL RECURRENCE FOLLOWING RADICAL PERINEAL PROSTATECTOMY IN A LARGE CONTEMPORARY SERIES: A DETAILED ASSESSMENT OF MARGIN STATUS AND LOCATION

Abstract

on biochemical failure (BCF), metastasis and survival were correlated, with a median follow-up of 99 months, Positive EPE and positive surgical margin ( EPE Margin), 2. Positive EPE and negative surgical margin ( EPE-Margin), 3. Negative EPE and positive surgical margin (-EPE Margin), and 4. Negative EPE and negative surgical margin (-EPE-Margin). RESULTS: Although both EPE (H.R.2.68, C.I. 1.23 & 5.82)and PSM (H.R.2.53, C.I. 1.25 & 5.13) were independent predictors of biochemical failure (BCF), only EPE was associated with metastasis and death from prostate cancer In addition, patients with EPE Margin or EPE-Margin had higher risks of BCF, metastasis and death from prostate cancer than patients with -EPE Margin or -EPE-Margin. Patients with a non-focal PSM 0.1 mm had a significantly higher risk of BCF compared with those with a focal PSM 0.1 mm (P value 0.028). CONCLUSIONS: Our study confirms the value of in depth pathologic analysis and reporting on radical prostatectomy specimens. The results support the concept of selective adjuvant radiotherapy in patients with EPE, based on focality and extent of EPE as well as extent of PSM, to minimize the likelihood of BCF.