Abstract
Decarboxylation is the simplest degradation reaction that can be applied to nicotinic acid. This chapter focuses on the degradation of nicotinic acid and related compounds. The degradation pathway is outlined in the chapter. N-benzoyl-5-amino-4-carboxyvaleric acid and 5-amino- 4-carboxy-valeric acid are new compounds discovered and the proof of their structures is reported. The reagents used in the degradation are nicotinic acid, benzoyl chloride, urea, or sulfuric acid. The apparatus used for the catalytic hydrogenation of nicotinic acid are tabulated. Before nicotinic acid- 14 C is submitted to the chemical degradation, it must be radiochemically pure. The method is used routinely for purifying nicotinic acid from extracts and whole cells of bacteria after incubation with radioactive substrates. The nicotinic acid can be assayed by a rapid chemical spectrophotometric method. The procedure involves the collection of CO 2 and conversion to BaCO 3 and measurement of radioactivity, hydrogenation, and decarboxylation of nicotinic acid. The use of 3 H: 14 C ratios for the determination of 14 C distribution are also focused. The results from the degradation of various labeled, authentic samples of nicotinic acid are tabulated.
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