1082 IL-27 expressed in the tumor microenvironment is correlated with PD-L1 levels and can induce PD-L1 expression on immune and tumor cells

Abstract

BackgroundInterleukin (IL)-27 is a heterodimeric cytokine expressed by myeloid cells that is known to reduce the intensity and duration of immune responses. IL-27 signaling via IL-27RA receptor augments the expression...