1082 Continuous Glucose Monitoring in Morbidly Obese Children with Normal Fasting Bg and Normal Ogtt

Abstract

This study has been undertaken to assess the glucose metabolism disorder by CGMS in morbidly obese children (BMI > 28) who have normal fasting glucose level and normal oral glucose tolerance. Methods: Ten morbidly obese children were studied. Interstitial fluid (ISF) glucose levels were measured by CGMS for 72 hours as well as by self-monitored blood glucose (SMBG) (3-4 times per day). The circulating fasting glucose, insulin, c-peptide, free T4, TSH, and HbA1C concentrations were measured. Results: The glucose levels in ISF measured by CGMS were highly correlated with those in capillary samples (r=0.742, P 7.6 mmol/L 2 h after food intake) and one had a diabetic curve (T2DM) (BG > 11.2 mmol/L 2 h after food intake). None of the children had elevated HbA1C level. Hyperinsulinemia and/or high C-peptide was recorded in 9 out of the 10 children. Conclusions: Our data suggest that glucose metabolism disorder including impaired postprandial glycemia and type 2 DM can be early diagnosed in morbidly obese children using CGMS when fasting BG and HbA1C levels are still normal. Further studies are required to improve the criteria of early diagnosis of glycemic abnormalities using CGMS.