108 P - Histological and clinical response evaluation to primary chemotherapy in local - advanced breast cancers

Abstract

Purpose To evaluate the curative potential of primary chemotherapy in term of clinical, histological response and survival in local-advanced breast cancers. Patients and Methods 76 patients with local-advanced breast cancera (stage IIIA - IIIB) were treated in two sequences: group A: 29 patients with 4–6 cycles (CMF/FEC) chemotherapy, local-radiotherapy and surgery; group B: 47 patients with radiotherapy and surgery. Two types of histological response (H.R.) have been individualized in 76 radical mastectomy specimens: complete HR without microscopic disease and incomplete HR, with residual tumor cells or histological tumor structure. An univariate analyis of six prognostic variable (age, Kamofski performance status, clinical, histological response and therapeutical sequence) was performed using Kruskall-Wallis and Kaplan-Meier method. Results 6 clinical complete responses (CR), 8 complete histological responses (HR) and 38% mortality rate was find in group A and 0 cases of complete HR and a 68% mortality rate at 36 weeks in group B. This difference is statistically significant (p = 0,002 for CR and p = 0,005 for HR). The performance status at the diagnosis moment proved to be statistically significant for the clinical response and survival. Conclusion Neo-adjuvant chemotherapy in local-advanced breast cancers is effective in local control and survival. To evaluate the curative potential of primary chemotherapy in term of clinical, histological response and survival in local-advanced breast cancers. 76 patients with local-advanced breast cancera (stage IIIA - IIIB) were treated in two sequences: group A: 29 patients with 4–6 cycles (CMF/FEC) chemotherapy, local-radiotherapy and surgery; group B: 47 patients with radiotherapy and surgery. Two types of histological response (H.R.) have been individualized in 76 radical mastectomy specimens: complete HR without microscopic disease and incomplete HR, with residual tumor cells or histological tumor structure. An univariate analyis of six prognostic variable (age, Kamofski performance status, clinical, histological response and therapeutical sequence) was performed using Kruskall-Wallis and Kaplan-Meier method. 6 clinical complete responses (CR), 8 complete histological responses (HR) and 38% mortality rate was find in group A and 0 cases of complete HR and a 68% mortality rate at 36 weeks in group B. This difference is statistically significant (p = 0,002 for CR and p = 0,005 for HR). The performance status at the diagnosis moment proved to be statistically significant for the clinical response and survival. Neo-adjuvant chemotherapy in local-advanced breast cancers is effective in local control and survival.