108 An integrative multi-omic analysis reveals a major metabolic rewiring between keratinocytes from babies and adults

Abstract

Even though its development starts early in utero, neonatal skin remains immature at birth relative to adult and undergoes a maturation process during the first years of life. It is now established that in newborns compared to children and adults, skin has a thinner stratum corneum, less natural moisturizing factors and lipids, a higher cellular turnover, and a higher permeability. Epidermal renewal relies on the balance between proliferation and differentiation of epidermal basal cells as well as removal of corneocytes by desquamation to maintain skin homeostasis or to restore epidermal structure and functions.