1077 Prospective assessment of cancer incidence and antipyrine metabolism

Abstract

Our previous studies revealed faster metabolism of antipyrine among lung cancer patients and their first degree relatives in comparison with subjects without cancer history in their families. Among 95 relatives of 27 lung cancer patients and 277 controls cancer morbidity during the period of eight years was analysed. Forty-two subjects from lung cancer families and 55 subjects from control families had previously assessed antipyrine metabolism. Two lung cancer cases and 8 non tobacco related cancers were noticed in lung cancer families. In the control group no one developed lung cancer. Also one case of tobacco related cancer and 11 cases of non tobacco related cancers were noticed in controls. The relatives of lung cancer patients in whom lung cancer was diagnosed had very fast antipyrine metabolism. The possible risk for lung cancer in families of lung cancer patients and connection with antipyrine metabolism were discussed.