1075P Tobacco smoking related mutational signatures (MS) in classifying smoking and non-smoking associated metastatic non-small cell lung cancer (mNSCLC)

Abstract

Patient-reported smoking history is frequently used as stratification factor or for subgroup analyses in NSCLC directed clinical research, even though this classification does not fully reflect the mutational processes in a tumour. Additionally, the label ‘smoker’ can add to the lung cancer stigma. Next generation sequencing can be used to identify MS associated with tobacco smoking, such as the single base MS (SBS) 4 and indel based MS (ID) 3. This provides an opportunity to redefine the classification of smoking and non-smoking associated NSCLC based on individual genomic tumour characteristics.