Abstract
Objective: NKDC are a novel subtype of dendritic cells (DC) with natural killer (NK) cell properties, as they can lyse tumor cells, present antigen to T cells and secrete IFN-γ. IL-15 is known to be an important regulator of NK cell ontogeny. We hypothesized that IL-15 is also essential for the development, survival, and proliferation of NKDC. Methods: Splenocytes from IL-15−/− and wild type B6 mice were analyzed via flow cytometry for NK cells and NKDC. IL-15−/− mice were treated with i.p. administration of exogenous IL-15 (1 μg/day) and splenocytes were analyzed at serial time points.
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