#107 : Association Between COVID-19 Vaccination Status and Spontaneous Abortion in Pregnant Women

Abstract

Background and Aims: Pregnant women are at greater risks for morbidity and mortality if infected by the COVID-19. Vaccination is critical in mitigating the risks. However, there is still limited data around safety profiles of COVID-19 vaccines in pregnant women especially in Indonesia. Therefore, this study is aimed to determine the association of COVID-19 vaccination status on the occurrence of spontaneous abortion in pregnant women in Indonesia. Method: This cross-sectional study was carried out from March-June 2022 at a private maternity clinic in Medan, Indonesia. Participants who agreed to participate were asked to sign the informed consent. Participants then were interviewed, and their diagnosis was confirmed using ultrasonography. Demographic data, vaccination status, parity, gestational age and the diagnosis were collected and statistically analyzed. The Chi-square test or Fisher’s exact test were done to analyze the categorical variables. Results: Of the 319 participants, 267 (84%) vaccinated and 52 (16%) unvaccinated. All the vaccinated participants received at least 1 dose to 3 doses of COVID-19 vaccine before pregnancy confirmation. There were 70 (22%) participants with spontaneous abortion and 249 (78%) with normal pregnancy. All our participants were having < 20 weeks of gestation, and majority were in reproductive age (82%) and primiparous (55%). Multiparity or gestational age were associated with spontaneous abortion occurrence (p < 0.05). We did not find association between pregnant women vaccination status and spontaneous abortion occurrence (p > 0.05). Conclusion: Our data indicated that COVID-19 vaccination history was not associated with spontaneous abortion occurrence, and thus, adding information regarding the safety of COVID-19 vaccination in pregnancy, especially in Indonesia.