Abstract
Copy number alterations (CNAs) are common genetic features in cancer with prognostic and therapeutic implications. At our institutional Molecular Tumor Board we introduced an ultra low-coverage Whole Genome Sequencing (ulcWGS, <0.5x coverage) to estimate numerical karyotype and CNAs. We performed this technique on 128 solid tumor samples from 2018 to 2022. Here we report 3 exemplary cases in which we detected potentially targetable CNAs via ulcWGS.
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