106P Ultra low-coverage whole genome sequencing for precision oncology in solid tumors

Abstract

Copy number alterations (CNAs) are common genetic features in cancer with prognostic and therapeutic implications. At our institutional Molecular Tumor Board we introduced an ultra low-coverage Whole Genome Sequencing (ulcWGS, <0.5x coverage) to estimate numerical karyotype and CNAs. We performed this technique on 128 solid tumor samples from 2018 to 2022. Here we report 3 exemplary cases in which we detected potentially targetable CNAs via ulcWGS.