1068 Relationship between ambulatory artery stiffness index and coronary atherosclerosis in hypertensive women

Abstract

Introduction: The ambulatory arterial stiffness index (AASI) derived from ambulatory blood pressure (BP) monitoring recordings is an indirect marker of arterial stiffness. We evaluated relationship between AASI and coronary artery disease (CAD) in hypertensive women. Methods: To the study group of 529 female was included (mean age 65.0 ± 8.6 years). In all patients 24-hour blood pressure monitoring and coronary angiography was performed (significant coronary atherosclerosis was recognized as at least 70% lumen stenosis of at least one coronary artery). AASI was defined as 1 minus the regression slope of 24-hour DBP on 24-hour SBP, and was calculated by standard and symmetric regression. Results: Study population was divided into two groups: with CAD (n = 276, mean age 66.4 ± 8.4 y.) and without CAD (n = 253, mean age 63.4 ± 8.4 y.). Higher value of AASI was found in CAD group than without CAD (0.33 ± 0.05 vs. 0.31 ± 0.05, p < 0.01). There was significant relationship between AASI and age in CAD group (r = 0.49, p < 0.01) and without CAD (r = 0.35, p < 0.01) as well. In CAD group in comparison to no CAD group, the stepwise multiple linear regression model reveled that AASI was independently related with age (β=0.44, p < 0.001), BMI (β=0.21, p < 0.001) and number of significant coronary atherosclerotic lesions (β=0.1, p < 0.01). Conclusion: AASI is strongly dependent on age, BMI and number of coronary atherosclerosis lesions in hypertensive women with significant coronary atherosclerosis.