Abstract
The RheoSwitch|[trade]| two-hybrid gene regulation system is the most tightly regulated system available for induction of a transgene, which may be critical for some gene therapy applications. This ecdysone receptor (EcR)-based system uses non-steroidal ligands to induce transgene expression, and they have shown no pleiotropic effects in mammalian cells. Selectivity for ligands of different chemotypes has been created in the ecdysone system by mutating the ligand-binding pocket of the receptor. We have identified and developed multiple ligand-receptor pairs, which respond orthogonally and can be combined to create a multiplexed gene regulation system.
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