1062 ES009, a LILRB2-specific blocking antibody, reprograms myeloid cells into pro-inflammation phenotype and potentiates T cell activation

Abstract

BackgroundThe ITIM-containing inhibitory receptor leukocyte immunoglobulin-like receptor B 2 (LILRB2, also known as ILT4) is predominantly expressed on myeloid-lineage cells, including monocytes, macrophages, dendritic cells and granulocytes, and is emerging...