Abstract
Introduction: Disorders of lipids metabolism, particularly elevated cholesterol concentration are favouring factors of atherosclerotic changes in the arteries. The lipids metabolism may be the results of the influence of genetic as well as environmental factors. Aim: The aim of the present study was the evaluation of the concentration of triglycerides, total cholesterol and its fractions and apolipoproteins in the newborns and infants with relation to intrauterine growth, nutritional status and method of feeding from the birth. Material and Methods: The research included 185 newborns and infants aged 2 -19 weeks. In all the studied children the gestational age, birth weight, body mass index (BMI) and the method of feeding was assessed. In the blood serum the concentrations of triglicerides, total cholesterol and its fractions: LDL, VLDL and HDL as well as apo-AI and apo-B were determined. Results: Concentrations of triglycerides and VLDL cholesterol were significantly lower (p< 0.05) in children with birth weight below 10-th percentile in relation to the gestational age. In children with BMI values over 90-th percentile concentrations of triglicerydes, total cholesterol, VLDL cholesterol and apolipoprotein B were significantly higher (p< 0.05). The concentrations of the total cholesterol, VLDL cholesterol, apo- AI and apo-B were higher in breast-fed children when compared to the children fed with formula (p< 0.05). Conclusion: The obtained results can suggest that the concentrations of lipids, lipoproteins and apolipoproteins in infants may depend on theirs intrauterine development, nutritional status and the method of feeding from the birth.
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