1060-P: Exploring Differences in the 24-Hour Glucose Cycle by Physical Activity Level in Women with Pregnancy Hyperglycemia

Abstract

Physical activity (PA) improves glucose levels. PA’s impact on the 24-hour glucose cycle in pregnancy hyperglycemia is unknown. This study examined baseline data from women participating in a small pilot feasibility randomized controlled trial. At baseline, they completed a survey which included the Stanford Leisure-Time Activity Categorical Item (L-Cat) for comparison to national PA recommendations. PA over the past month was assessed. Dexcom G6 CGMs linked to blinded receivers were worn for 7 days. Typical 24-hour glucose functions were estimated with B-splines and generalized regression analyses controlling for gestational diabetes (GDM) conducted in JMP. CGM was available for 14 participants; 4 (29%) had GDM and 3 (21%) reported meeting PA recommendations. Mean glucose was 91.5 mg/dl (SD 17) for sufficient PA and 93.6 mg/dl (SD 20) for insufficient PA. Figure 1 displays the 24-hour glucose functions (3rd degree polynomials with 17 knots) for sufficient PA (red) versus insufficient PA (blue) . Lower glucose was observed in the early morning, i.e., from midnight through approximately 6am and likely fasted, in sufficient versus insufficient PA, but the difference did not attain statistical significance. Glucose was higher in those with GDM, controlling for PA (P < .05) . Findings in a small sample of women with pregnancy hyperglycemia suggest that PA may improve early morning glucose. Disclosure S.F.Ehrlich: None. B.G.Rand: None. N.Zite: None. K.B.Fortner: Other Relationship; Pfizer Inc. A.M.Paudel: None. C.Peterson: None. J.M.Maples: None. Funding K01DK105106