Abstract
Intravenous lipid emulsion (ILE) has emerged as a potential antidote for treatment of intoxication by lipophilic drugs. Despite conflicting pre-clinical (animal) data, its use continues to expand. The “lipid sink” theory, which is the prevailing theory on ILE mechanism of action, suggests that ILE generates a flux of drugs from the periphery into the vascular compartment, thereby reducing the target organ exposure and toxicity of lipophilic drugs. The primary aim of this pragmatic, real-life prospective cohort study was to compare efficacy (measured by patient survival to hospital discharge) of ILE during resuscitation of critically-ill poisoned patients intoxicated by xenobiotics with wide spectrum of lipophilicities (determined by the octanol water partition coefficient (Log P).
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