Abstract
Abstract Dopamine (DA) has received substantial attention due to its involvement in a wide array of neurological and psychiatric disorders, ranging from Parkinson's disease to affective disorders and schizophrenia. As a result, this system has been studied extensively at many levels of analysis. This is an exciting time for research into psychiatric disorders and the DA system, as evidenced by the convergence of basic neuroscience and clinical research studies on common pathophysiological targets. Dopamine itself has been described as involved in reward and addiction, in attention and compulsions, and in cognition and affect. However, recent studies suggest that the DA system may act to coordinate integration of information via selective potentiation of circuits or pathways. This suggests that DA is acting as a “glue” that holds together plastic relationships among diverse brain structures. This chapter focuses on the system physiology of the DA system in intact animals, how the DA system is regulated, and how dysregulation of this system may contribute to the pathophysiology of major psychiatric disorders.
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