1050P Association of ctDNA quantification with prognosis and early prediction of response to first-line osimertinib in NSCLC patients

Abstract

Osimertinib is the new standard of care in epidermal growth factor receptor (EGFR)-mutated non-pretreated advanced non-small-cell lung cancer (NSCLC). The MELROSE study, a multicentric, open label, phase II trial (NCT03865511) was designed to identify resistance mechanisms at the time of disease progression in treatment-naive EGFR-mutated NSCLC patients receiving osimertinib. While these analyses are in progress, we explored secondary endpoints including ctDNA analysis.