Abstract
The aim of this study is to investigate the neuronal phospho-PKC kinase involved in signal transduction of spinal cord and post-synaptic dorsal column (PSDC) pathway in a rat model of visceral pain. Visceral painful stimulation causes spinal neuro-plasticity changes and neuronal calcium-dependent protein kinase (PKC)-mediated neuronal signaling pathway may contribute to the central mechanism of visceral pain. Recent clinical data suggested that neurosurgical interruption of PSDC pathway by performing midline myelotomy in patients with severe cancer pain can greatly alleviate intractable visceral pain.
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