Abstract

Rangeliosis•Cause: Rangelia vitalii, a protozoan parasite of the phylum Apicomplexa, class Aconoidasida, order Piroplasmida; phylogenetically close to the family Babesiidae.•First Described: 1908, in dogs from Brazil (Carini, 1908).•Affected Hosts: Domestic dogs and wild canids (the crab-eating fox Cerdocyon thous, and the pampas fox Lycalopex gymnocercus).•Geographic Distribution: South America, especially in the south and south-east of Brazil, Argentina, and Uruguay.•Mode of Transmission: Amblyomma aureolatum ticks.•Major Clinical Signs: Lethargy, inappetence, weakness, weight loss, fever, pallor, jaundice, splenomegaly, lymphadenomegaly, pelvic limb edema, and hemorrhagic disorders including persistent hemorrhage from the tips and external surface of the pinnae, nose (epistaxis), oral cavity (including hematemesis), venipuncture sites, and GI tract (hemorrhagic diarrhea).•Differential Diagnosis: Other tick-borne diseases (e.g., canine babesiosis and canine monocytic ehrlichiosis), leptospirosis, leishmaniosis, immune-mediated disorders.•Human Health Significance: There is no evidence that R. vitalii can infect humans.

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