Abstract

IgG against CMV was measured by enzyme immunoassay in 306 members of 71 monozygotic twin families including 135 children. 19% of children were seropositive (SP) compared to 46% of adults. 56% af mothers were SP compared to 35% of fathers (X2 = 5.5, 1df, p<0.05). In 7 families with only a SP father, only one of 17 children was SP, while 12 of 43 children were SP in 22 families where of the parents only the mother was SP. 28% (20/72) of children in 40 families with a SP mother were SP compared to only 9% SP children (6/63) in 31 families without a SP mother. (X2 =6, 1df, p<0.02). Among nontwin sibs and adult co-twins there was. no correlation in antibody status. Antibody status was however highly correlated among 28 sets of adolescent twins (X2 = 19, 1df p<0.001). Among couples the frequency of a SP spouse was independent of whether his or her mate was SP. In contrast there was a high correlation for the presence of antibody Against herpes simplex in a subset of 19 couples (X2=11.3, 1 df p<0.001). These data are consistent with the maternal-child transmission of CMV but provide no evidence for transmission between marital partners or nontwin sibs.

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