1041 THE EFFECTS OF REGULAR AND DECAFFEINATED COFFEE ON VOIDING SYMPTOMS IN YOUNG HEALTHY VOLUNTEERS

Abstract

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Incontinence, Evaluation & Therapy (II)1 Apr 20131041 THE EFFECTS OF REGULAR AND DECAFFEINATED COFFEE ON VOIDING SYMPTOMS IN YOUNG HEALTHY VOLUNTEERS Andrea Staack, Brian Distelberg, Christopher Chung, Kirk Baker, Amy Schlaifer, Kirk Anderson, and Herbert Ruckle Andrea StaackAndrea Staack Loma Linda, CA More articles by this author , Brian DistelbergBrian Distelberg Loma Linda, CA More articles by this author , Christopher ChungChristopher Chung Loma Linda, CA More articles by this author , Kirk BakerKirk Baker Loma Linda, CA More articles by this author , Amy SchlaiferAmy Schlaifer Loma Linda, CA More articles by this author , Kirk AndersonKirk Anderson Loma Linda, CA More articles by this author , and Herbert RuckleHerbert Ruckle Loma Linda, CA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.627AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Objective: About 15% of the U.S. general population report having stopped drinking coffee altogether, citing concerns about side effects of caffeine. To our knowledge, no studies have been conducted that explore the effects of higher dosage coffee and decaffeinated coffee on lower urinary symptoms in a younger population. Therefore, the main purpose of this study is to compare decaffeinated with regular coffee and their effects on LUTS in young volunteers, who are not regularly exposed to caffeine, using water consumption as the internal control. METHODS Methods: In this randomized prospective longitudinal study all subjects underwent a 5-day washout phase, were they were restricted from consuming any caffeinated products, followed by the 5-day coffee phase. During the treatment phase the subjects were randomly assigned to drink 24 oz. of either decaffeinated coffee (12 mg caffeine) or regular coffee (450 mg caffeine). The coffee was brewed blindly in a standardized fashion. The study concluded with a 5-day washout phase. Throughout the three phases of the study subjects filled out voiding logs, health surveys, UDI-6, interstitial cystitis problem and symptom indices (ICSI, ICPI) at eight different time points. Continuous variables were compared using the ANOVA and post hoc t-test comparison test. RESULTS Results: Between April and June 2012, 49 healthy individuals between the ages of 18 and 45 years (mean age: 27) were enrolled and completed the study. 25 subjects were randomized into the regular coffee and 24 into the decaffeinated coffee arm and underwent a pre and post treatment washout phases. Consumption of 450mg caffeine produced significant increase in urine output at the first day of treatment (p<0.01), which normalized after three days of washout. The ICSI was elevated in the coffee arm (p<0.03). There was no difference between the decaffeinated treatment and the water phase (wash out) on any of the outcome measures. CONCLUSIONS Conclusion: This is the first randomized prospective study, which showed a significant increase in LUTS and voided volume during consumption of high dosage coffee, when compared to decaffeinated coffee or water intake. Symptoms were normalizing three days after termination of coffee. Findings suggest consuming decaffeinated coffee instead of regular coffee to avoid LUTS and increase of urine out put. Further studies are warranted to assess effects of caffeine in patients presenting with overactive bladder symptoms to improve counseling. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e427 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Andrea Staack Loma Linda, CA More articles by this author Brian Distelberg Loma Linda, CA More articles by this author Christopher Chung Loma Linda, CA More articles by this author Kirk Baker Loma Linda, CA More articles by this author Amy Schlaifer Loma Linda, CA More articles by this author Kirk Anderson Loma Linda, CA More articles by this author Herbert Ruckle Loma Linda, CA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...