103P Rate of BRCA1/2 pathogenic variants according to family and personal history of cancer in a large cohort of triple-negative breast cancer (TNBC) patients (pts) younger than 60 years of age

Abstract

Triple-negative breast cancer (TNBC) patients (pts) are at increased likelihood of carrying a BRCA pathogenic variant. Clinical testing guidelines recommend BRCA genetic testing for TNBC pts aged 60 years or younger, independently from family history. We here aim to determine rate of BRCA pathogenic variants according to family and personal history in a large cohort of TNBC pts from Northern Italy.