1036 A Unique Gene Expression Profile May Predict Responsiveness to Dietary Elimination With Six Food Elimination Diet in Adults With Eosinophilic Esophagitis

Abstract

ling for time-specific treatment components (dietary restrictions, reflux medication, swallowed steroids), child's age, and number of baseline symptoms. Results: Sixty-six children (age 2-18 years old; mean age, 7.9 yrs +/4.6 y; 79% male; 89% white) completed 3 assessments. Some patients (n=12) received a new diagnosis of EoE; others had been diagnosed previously (n=54). At baseline, patients reported a mean of 3.3 of 8 EoE symptoms (SD, 2.2; range, 0-8); the mean of summed severity scores was 5.5 (SD, 4.4; range, 0-17). Total number of symptoms was inversely correlated with parent and child reported PedsQLTM Total scores, r = -0.32 (n = 66) and r = -0.40 (n = 41) (P's < .01). Symptom scores decreased significantly from baseline to 6 months (P = .03), with a mean decrease of 1.3. PR-PedsQLTM Total scores increased across time points (P's < .004); from baseline to 6 months followup, PR-PedsQLTM Total scores increased a mean of 5.4 points. PR-PedsQLTM Physical and Psychosocial subscale scores also improved an average of 3.6 and 5.4 points, respectively (P = .04 and P = .001). For children's self-reported QoL, only the Psychosocial subscale scores increased a mean of 5.4 points over time (P = .05). Conclusion: Children with EoE who entered multidisciplinary tertiary care programs had decreased symptoms and increased QoL over a 6-month period. Support: This research was conducted with support from the Investigator-Sponsored Study Program of AstraZeneca, LP and from the NIH/NCRR Colorado CTSI Grant Number UL1 RR025780.