1031 ASSOCIATION BETWEEN SERUM LEPTIN LEVEL AND SEXUAL BEHAVIOR IN PSYCHOLOGICALLY STRESSED MALE RATS

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research (II)1 Apr 20131031 ASSOCIATION BETWEEN SERUM LEPTIN LEVEL AND SEXUAL BEHAVIOR IN PSYCHOLOGICALLY STRESSED MALE RATS Yoshiji Miwa, Masaya Seki, and Osamu Yokoyama Yoshiji MiwaYoshiji Miwa Fukui, Japan More articles by this author , Masaya SekiMasaya Seki Fukui, Japan More articles by this author , and Osamu YokoyamaOsamu Yokoyama Fukui, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.616AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Chronic psychological stress has been linked to a number of negative health consequences, including effects on the cardiovascular, endocrine, immune, and reproductive systems. Recently it has been reported that despite a decrease in both body weight gain and adipose tissue weight, chronic restraint stress evoked low-grade inflammation in murine adipose tissue, similar to that seen in metabolic syndrome. This inflammatory change involved the induction of proinflammatory adipokines and a decrease in adiponectin. Leptin, a protein hormone produced by adipose tissue, plays a role in regulating energy intake and expenditure, and facilitating sexual behavior. The aim of this study was to investigate the association between serum leptin level and sexual behavior in psychologically stressed male rats. METHODS Adult male Wistar-Kyoto rats were divided into 2 groups: a control group (n=16) and a psychological stress loading group (PS, n=16). The PS rats were exposed to psychological stress for 2 hours per day for 10 consecutive days, and the control rats were exposed to clean and empty cages (sham stress) for 2 hours per day for 10 consecutive days. Psychological stress was induced by the communication box. After the last stress loading, their copulatory behavior with receptive females was tested. During the test, the mount latency, intromission latency, and ejaculation latency were recorded. Prolonged latencies show sexual behavior to be reduced. Immediately after the copulation test, blood samples were collected and serum leptin, corticosterone, total testosterone, free testosterone, LH, FSH and estradiol levels were determined. RESULTS The PS rats had significantly longer latencies, lower leptin level, and higher corticosterone level than did the control rats (p<0.01, 0.001 and 0.019, respectively). There was a significant negative correlation between latencies and serum leptin level. CONCLUSIONS These results show that psychologically suppressed masculine sexual behavior could be associated with decreased serum leptin level caused by stress-induced dysfunctional adipose tissue. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e422 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yoshiji Miwa Fukui, Japan More articles by this author Masaya Seki Fukui, Japan More articles by this author Osamu Yokoyama Fukui, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...