103 JAK-STAT activation in anti-PD-1 therapy-associated granuloma annulare

Abstract

Granuloma annulare (GA) is a cutaneous condition that can arise idiopathically or in association with risk factors such as diabetes, microvascular damage, and more recently, the use of anti-programmed cell death protein-1 (PD-1) agents. It can be difficult to treat as the pathogenetic mechanism is still unknown, but recent research has shown Janus kinase-Signal transducer and activator of transcription (JAK-STAT) pathway activation in idiopathic GA. Furthermore, tofacitinib has been seen to induce dramatic clinical improvement in patients with sarcoidosis and generalized GA.