Abstract
T-cells were similarly decreased in all fibrotic-groups. NK-cells decreased following fibrosis in control groups AD however, both treated groups BC as compared to WT. In-vitro, increased pGEM7-concentrations elevated hepatic-stellate-cell (HSC) proliferation, however, T-cell proliferation decreased. Conclusions: TLR9 activation had inversed effects on lymphocytes and HSCs. The net balance of TLR9 activation in WT, displayed significant anti-fibrotic activity, accompanied by CD8 suppression and increased NK-cells. TLR9 fibrosis model had decreased fibrosis (due to direct HSC block of activation) but increased ALT levels (due to increased lymphocyte proliferation and hepatocyte injury).
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