Abstract
In vertebrate embryos, hematopoietic stem cells (HSCs) are generated from a subset of the aortic endothelium, the hemogenic endothelium, via a process called endothelial-to-hematopoietic transition (EHT). In our studies aimed at obtaining a mechanistic insight into EHT we have identified cell type and stage specific enhancers of Runx1– a critical regulator of EHT – and generated transgenic enhancer-reporter mouse models to isolate hemogenic endothelium. Functional and molecular analysis of hemogenic endothelium established that these cells undergo dynamic changes early in development, rewriting the timeline of hematopoietic specification. We constructed a gene regulatory network underlying EHT and identified new candidate players involved in the birth of hematopoietic stem cells.
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