Abstract
The identification of reliable biomarkers of immune checkpoint inhibitors (ICI) efficacy is a high priority. Host-related parameters including gut microbiota (Routy B Science 2018, Derosa L Nature Med 2022) and resting energy expenditure (Boudou-Rouquette P Ebiomedecine 2021) have recently emerged. We hypothesized that 18F-FDG colonic uptake might be a surrogate marker for gut microbiome composition, influence energy expenditure and help to identify responders to ICI.
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