Abstract
Our laboratory previously identified a novel role for vascular cell adhesion molecules in promoting the awakening of dormant Haematopoietic Stem Cells (HSCs) in the bone marrow (BM) (Nat Med 2012). Now we show vascular niche adhesion can trigger a cascade of intracellular signalling events that can metabolically and transcriptionally reprogram a cell. For bone marrow (BM) Haematopoietic Stem and Progenitor Cells (HSPC) these open new avenues to tailor immune response and recovery during stress. Malignant cells also take advantage of these pathways. In malignant cells, aberrant glycosylation associated with oncogenic transformation promotes expression of surface ligands that utilise these pro-survival pathways. The discovery of how cellular adhesion acts to prime leukocytes for appropriate inflammatory response and how this evolutionary-ancient signalling network is hijacked by malignant cells for growth and survival, are the subject of this talk.
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