1020-P: Diabetes Phenotypes among Women with Diagnosed Diabetes in the United States

Abstract

Tailoring diabetes management strategies based on phenotyping presentation may be an approach to address racial disparities in diabetes outcomes among women. We identified diabetes phenotypes and their distribution by race/ethnicity among US women.Methods: We analyzed metabolic parameters of n=497 women ages 30-64 with diagnosed diabetes assessed in the National Health and Nutrition Examination Surveys (1988-1999 and 1999-2013). Phenotypes were identified through latent class analysis. The method grouped women into homogeneous clusters (“latent classes”) based on observed patterns of HbA1c, BMI, HOMA2-IR, waist circumference (WC), triglycerides (TG), systolic blood pressure (SBP), and duration of diabetes.Results: We identified three major phenotypes of diabetes. On average, Phenotype 3, “least controlled” had the highest levels of glycemia and insulin resistance, as well as anthropometric and metabolic risks. In contrast, Phenotype 1, “better control”, had the lowest BMI, WC, HOMA2-IR, TG levels and moderate HbA1c, SBP. Phenotype 2, “moderate control” had moderate BMI, HbA1c, HOMA2-IR, WC, TG and SBP. The prevalence of the least controlled phenotype ranged from 21.8% in Hispanic women to 28.3% in black women.Conclusion: We observed three distinct diabetes control phenotypes among US women. The phenotype with least control was highest in African American women.View largeDownload slideView largeDownload slide DisclosureS. A. Patel: None. D. Choi: None.FundingNational Institutes of Health (P30DK111024, P30DK111024-04S2)