1020-P: A New Ambulatory Glucose Profile Report to Evaluate and Support Glucose Control in People after Bariatric Surgery

Abstract

Bariatric surgery increases postprandial glucose excursions with higher peaks and lower nadirs. Etiologically linked is the phenomenon of postbariatric hypoglycaemia (PBH), an increasingly recognized metabolic disorder. Continuous glucose monitoring (CGM) has become an important tool in the diagnosis and management of PBH. The Ambulatory Glucose Profile (AGP) is an internationally recognized and standardized format that provides structured and graphical compilation of CGM data to guide treatment decisions in people with diabetes. However, its applicability to patients suffering from bariatric surgery-induced dysglycaemia, such as PBH, remains limited. Based on the collection of CGM data in healthy individuals and post-bariatric surgery patients with and without PBH, we selected a set of summary statistics that are important to diagnose the condition, decide on and evaluate the efficacy of therapeutic strategies. We propose a novel AGPr which contains the following: %time spent with non-physiological glucose values, the diurnal distribution of hypoglycaemic events (including level and duration) and information on postprandial glucose excursions by colour-coding of rate of glucose change and variability metrics. The new AGPr uses data generated by CGM to provide a rapid visual presentation of glucose dynamics and hypoglycemia burden in post-bariatric surgery individuals. Disclosure L.Cossu: None. G.Cappon: Consultant; Dexcom, Inc. D.Herzig: None. A.Facchinetti: None. L.Bally: Research Support; Dexcom, Inc., Ypsomed AG. Funding University of Padova, Italy (SID-Networking Project 2021)