101 INCREASED CANCER CELL PROLIFERATION IN PROSTATE CANCER PATIENTS WITH HIGH LEVELS OF SERUM FOLATE

Abstract

You have accessJournal of UrologyProstate Cancer: Basic Research I1 Apr 2010101 INCREASED CANCER CELL PROLIFERATION IN PROSTATE CANCER PATIENTS WITH HIGH LEVELS OF SERUM FOLATE Jeffrey Tomaszewski, Jessica Cummings, Anil Parwani, Rajiv Dhir, Joel Mason, Joel Nelson, Dean Bacich, and Denise O'Keefe Jeffrey TomaszewskiJeffrey Tomaszewski Pittsburgh, PA More articles by this author , Jessica CummingsJessica Cummings Pittsburgh, PA More articles by this author , Anil ParwaniAnil Parwani Pittsburgh, PA More articles by this author , Rajiv DhirRajiv Dhir Pittsburgh, PA More articles by this author , Joel MasonJoel Mason Boston, MA More articles by this author , Joel NelsonJoel Nelson Pittsburgh, PA More articles by this author , Dean BacichDean Bacich Pittsburgh, PA More articles by this author , and Denise O'KeefeDenise O'Keefe Pittsburgh, PA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.150AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES A recent placebo-controlled prospective clinical trial of folic acid supplementation revealed an increased incidence of prostate cancer in the treatment group. The present study evaluates serum and prostate tissue folate levels in men with prostate cancer, compared to histologically normal prostate glands from cancer-free organ donors. METHODS Serum and/or prostate tissue folate concentration were measured in 86 patients undergoing radical prostatectomy and from 32 cancer-free organ donors. Expression of Ki67 and PSMA were assessed in a subset of these tissues. RESULTS Mean serum folate concentrations were significantly higher at all age ranges in men with prostate cancer compared to cancer-free organ donors (p<0.002; Figure 1).Fasting serum folate levels were positively correlated with prostate cancer tissue folate content (n= 15; Spearman Correlation r= 0.577, p<0.03). Mean tissue folate levels in prostate cancers were also significantly higher than in cancer-free prostates from age-matched organ donors (p<0.02). Among patients with Gleason Score 7 disease, the mean proliferation index was 6.17 ± 3.2% and 0.86 ± 0.92% in patients in the highest (117±15nM) and lowest (18±9nM) quintiles for serum folate, respectively (p<0.0001; Figure 2). CONCLUSIONS To our knowledge, this is the first report of a positive correlation between serum folate and prostate cancer tissue folate. Increased cancer cell proliferation in men with higher serum folate concentrations is consistent with an increase in prostate cancer incidence observed with folate supplementation. Unexpectedly, more than 25% of the prostate cancer cohort had a serum folate concentration 6-fold greater than considered adequate, suggesting either regular supplement use and/or altered folate metabolism. With widespread dietary folate supplementation the relationship between folate intake and prostate cancer should be better defined. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e41-e42 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jeffrey Tomaszewski Pittsburgh, PA More articles by this author Jessica Cummings Pittsburgh, PA More articles by this author Anil Parwani Pittsburgh, PA More articles by this author Rajiv Dhir Pittsburgh, PA More articles by this author Joel Mason Boston, MA More articles by this author Joel Nelson Pittsburgh, PA More articles by this author Dean Bacich Pittsburgh, PA More articles by this author Denise O'Keefe Pittsburgh, PA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...