1009 CYANIDIN-3-O-β-D-GLUCOPYRANOSIDE CONCENTRATED MATERIALS FROM MULBERRY FRUIT HAS A POTENCY TO PROTECT ERECTILE FUNCTION BY MINIMIZING OXIDATIVE STRESS IN A RAT MODEL OF DIABETIC ERECTILE DYSFUNCTION

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research II1 Apr 20121009 CYANIDIN-3-O-β-D-GLUCOPYRANOSIDE CONCENTRATED MATERIALS FROM MULBERRY FRUIT HAS A POTENCY TO PROTECT ERECTILE FUNCTION BY MINIMIZING OXIDATIVE STRESS IN A RAT MODEL OF DIABETIC ERECTILE DYSFUNCTION Woong Jin Bae, U. Syn Ha, Yong Sun Choi, Jang Ho Bae, Su Jin Kim, Hyuk Jin Cho, Sung Hoo Hong, Ji Youl Lee, Tae-Kon Hwang, and Sae Woong Kim Woong Jin BaeWoong Jin Bae Seoul, Korea, Republic of More articles by this author , U. Syn HaU. Syn Ha Seoul, Korea, Republic of More articles by this author , Yong Sun ChoiYong Sun Choi Seoul, Korea, Republic of More articles by this author , Jang Ho BaeJang Ho Bae Seoul, Korea, Republic of More articles by this author , Su Jin KimSu Jin Kim Seoul, Korea, Republic of More articles by this author , Hyuk Jin ChoHyuk Jin Cho Seoul, Korea, Republic of More articles by this author , Sung Hoo HongSung Hoo Hong Seoul, Korea, Republic of More articles by this author , Ji Youl LeeJi Youl Lee Seoul, Korea, Republic of More articles by this author , Tae-Kon HwangTae-Kon Hwang Seoul, Korea, Republic of More articles by this author , and Sae Woong KimSae Woong Kim Seoul, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1111AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The aim of this study was to evaluate C3G concentrated materials from mulberry fruit on improvement and protection for erectile function. METHODS Sprague-Dawley rats (12wks old) were divided into three groups (n=12 in each): normal control, diabetes (DM), and diabetes with C3G concentrated materials treatment (DM+C3G). DM and DM+C3G group received a single injection of streptozotocin (50mg/kg), and 4 wk after induction of diabetes, DM+C3G group were treated with daily concentrated materials treatment (10 mg/kg) dissolved in water for 8 wk. After 12 wk of streptozotocin injections, rats in each group underwent intracavernosal pressure measurement (ICP) and then the corporal tissues were sampled. RESULTS DM group showed markedly lower erectile parameters than those in the control group, whereas rats in the DM+C3G group showed improved erectile function by minimizing corporal apoptosis and increasing the expression of eNOS and nNOS protein. A significant increase in 8-hydroxy-2-deoxyguanosine (8-OHdG), the predominant marker of oxidative damage, was shown in the DM group compared with the normal group. However, in DM+C3G group 8-OHdG was statistically significantly reduced compared with DM group. With respect to Superoxide dismutase protein, western blot analysis revealed a significant decrease in DM group compared with the control group; however, it was expressed more in DM + C3G group than in the control group. CONCLUSIONS The current study is the first to suggest that C3G concentrated materials may have a potency to improve and protect erectile function under conditions of diabetes-induced oxidative stress. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e410 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Woong Jin Bae Seoul, Korea, Republic of More articles by this author U. Syn Ha Seoul, Korea, Republic of More articles by this author Yong Sun Choi Seoul, Korea, Republic of More articles by this author Jang Ho Bae Seoul, Korea, Republic of More articles by this author Su Jin Kim Seoul, Korea, Republic of More articles by this author Hyuk Jin Cho Seoul, Korea, Republic of More articles by this author Sung Hoo Hong Seoul, Korea, Republic of More articles by this author Ji Youl Lee Seoul, Korea, Republic of More articles by this author Tae-Kon Hwang Seoul, Korea, Republic of More articles by this author Sae Woong Kim Seoul, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...