1000P Screening cancer immunotherapeutic agents using high content imaging and analysis of immune-competent 3D InSight tumor models

Abstract

Dissecting the interaction of tumor cells with immune cells is essential to decipher the mechanism of immunotherapies. With our immune-competent 3D InSightTM tumor models we propose optimized in vivo-like conditions over standard cell cultures to assess how immune cells elicit effective responses against cancer. Moreover, we present a live-cell imaging approach to assess the efficacy of immune-targeting therapies with high-content imaging and analysis (HCA) techniques.