Abstract
Accumulating epidemiological evidence shows that diets rich in fruits, e.g., cherries, and vegetables can significantly reduce CVD risk. In this randomized, placebo‐controlled crossover study, we recruited 10 participants (38.1 ± 12.5 y; 8 females, 2 males) with BMI>25.0 (32.2 ± 4.6; 5 obese, 5 overweight) to consume 8 fl oz. daily of either 100% tart cherry juice or an alternate placebo beverage, for 4 weeks each with a 2 week intervening washout period. Fasting blood samples were collected at the beginning and end of each arm for measurement of biomarkers of dyslipidemia and glycemia. Total cholesterol (C) (188.1 ± 21.0 mg/dl) was not different between treatments (p>0.05) but plasma triglycerides (TG), TG/HDL‐C, and VLDL were significantly reduced 10%, 17% and 15%, respectively (p<0.05) after tart cherry juice consumption. LDL‐C and HDL‐C were not different between treatments. Baseline fasting glucose and insulin levels were 100.0 ± 10.3 mg/dl and 12.8 ± 5.8 uIU/ml, respectively. HOMA, QUICKI, and McAuley indices of insulin resistance were not significantly different at the end of both phases. Baseline hsCRP was 7.0 ± 5.2 mg/l indicating increased CVD risk in these participants. Consumption of tart cherry juice or placebo did not result in significant differences in hsCRP. Collectively, the data suggest that 100% tart cherry juice may reduce the risk of CVD by reducing plasma TG.
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