Abstract
The current in vitro study was designed to assess opioid peptides expression and inflammatory blunting in two rat experimental pancreatitis models, using human cultured cells, including PANC-1 cells derived from pancreatic cancer. Replication-defective HSV-1 vectors with human transgene proenkephalin cDNA (HSV-Enk), beta-galactosidase cDNA (control vector, HSV-beta-gal) or vehicle control were applied to cell cultures at Multiplicity of Infection ranges of 5.0-0.005. Enkephalin expression and aspects of inflammatory blunting were measured by immunocytochemistry, RT-PCR, cDNA microarrays, and immunoassays.
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