10 Gy versus 16 Gy electron beam boost dose in breast conservation therapy for early stage breast cancer: a decision analysis

Abstract

Purpose/Objective: Two published prospective randomized controlled trials (Lyon trial, 1997 and EORTC trial, 2001) demonstrated a reduction in local recurrence rates with the addition of an electron beam boost to the lumpectomy cavity after whole breast radiotherapy in breast conservation treatment of early stage breast cancer. The dose used for the electron beam boost, however, has not yet been evaluated in a randomized trial, raising the question of whether 10 Gy as used in the Lyon trial or 16 Gy from the EORTC trial offers the best benefit for these patients. To address this question we constructed a decision model to compare the life expectancy and quality-adjusted life expectancy of early-stage breast cancer managed with breast conservation treatment with the addition of a 10 Gy or 16 Gy boost.