Abstract
The division between neurology and psychiatry reflects an artificial divide. For many patients with complex neuropsychiatric presentations, the differential diagnosis includes a range of both neurologic and psychiatric conditions. This chapter details cognitive-affective-behavioral brain-symptom relationships with a focus on depression and psychotic spectrum symptoms. In the latter portions of the chapter, the range of neurological conditions with prominent cognitive, affective, perceptual, and behavioral manifestations are outlined. Moving forward, we encourage an integrated clinical neuroscience approach for the assessment, management and investigation of neuropsychiatrically complex brain disorders.
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