Abstract
Nexin was first identified in electron microscope images of axonemes as a linker that repeats every 96nm between adjacent outer doublet microtubules. The nexin links are thought to be protease-sensitive structures that limit microtubule sliding during the ciliary beat cycle. The dynein regulatory complex (DRC) was first described in genetic screens for suppressor mutations that restore motility to paralyzed radial spoke (RS) or central pair (CP) mutants. The DRC is thought to identify intermediates in the signaling pathway between the CP, RS, and dynein arms. Cryo-electron tomography of drc mutant axonemes revealed that the DRC is located within the nexin link, in close proximity to RS2 and a calmodulin spoke complex, and also serves as an adaptor that stabilizes the assembly of several inner arm dyneins. Recent studies have identified at least 11 DRC subunits and several other N-DRC-associated proteins. The implications of these findings for future studies of ciliary motility are discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
