10 Applications of Metal-Catalyzed Dynamic Kinetic Resolutions and Dynamic Kinetic Asymmetric Transformations for the Synthesis of Complex Molecules

Abstract

AbstractThe stereocontrolled synthesis of complex molecules is a key technology for the pharmaceutical, agrochemical, and fine-chemical industries, a well-established field of organic chemistry, and the ultimate proving ground for the value of newly developed synthetic methods. This chapter illustrates how metal-catalyzed dynamic kinetic resolutions (DKR) and dynamic kinetic asymmetric transformations (DYKAT) have been used in the synthesis of complex molecules such as natural products, pharmaceuticals, and chiral ligands. This approach has unique strategic advantages over other methods as it allows the use of racemic starting materials, where asymmetry is introduced at a later stage in a synthetic sequence and can even be used to set multiple stereogenic centers in a single step.