Abstract
The compound, C15H16N2O2, features a pyrroline ring fused with a seven-membered diazepine ring; the latter system adopts a boat conformation (with the methine C atom as the prow and the two C atoms of the aromatic ring as the stern). A CH2–CH2 segment of the pyrroline ring is disordered over two positions in a 1:1 ratio.
Highlights
The compound, C15H16N2O2, features a pyrroline ring fused with a seven-membered diazepine ring; the latter system adopts a boat conformation
A CH2–CH2 segment of the pyrroline ring is disordered over two positions in a 1:1 ratio
C2—N2—C9—C10 C12—N2—C9—C10 N2—C9—C10—C11 C10′—C9—C10—C11 C9—C10—C11—C12 N2—C9—C10′—C11′ C10—C9—C10′—C11′ C9—C10′—C11′—C12 C2—N2—C12—C1 C9—N2—C12—C1 C2—N2—C12—C11′ C9—N2—C12—C11′ C2—N2—C12—C11 C9—N2—C12—C11 O1—C1—C12—N2 N1—C1—C12—N2 O1—C1—C12—C11′ N1—C1—C12—C11′ O1—C1—C12—C11 N1—C1—C12—C11 C10′—C11′—C12—N2 C10′—C11′—C12—C1 C10′—C11′—C12—C11
Summary
Hanane Benzeid,a El Mokhtar Essassi,a Nathalie Saffon,b Bernard Garriguesc and Seik Weng Ngd*. Key indicators: single-crystal X-ray study; T = 193 K; mean (C–C) = 0.003 A; disorder in main residue; R factor = 0.049; wR factor = 0.146; data-to-parameter ratio = 12.7. The compound, C15H16N2O2, features a pyrroline ring fused with a seven-membered diazepine ring; the latter system adopts a boat conformation (with the methine C atom as the prow and the two C atoms of the aromatic ring as the stern). A CH2–CH2 segment of the pyrroline ring is disordered over two positions in a 1:1 ratio. Related literature Pyrrolo[2,1-c][1,4]benzodiazepines are potent, naturally occurring antitumor antibiotics produced by Streptomyces species; see: Cargill et al (1974); Thurston et al (1993). For the design and synthesis of DNA inter-strand cross-linking as well as conjugate agents to enhance the sequence selectivity and to increase selectivity for tumor cells, see: Bose et al (1992); Gregson et al (2004)
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