Abstract
The results of experimental investigation of an increase in the epidermal barrier permeability are presented. The results are obtained using the method based on the creation of permeability microzones (islets) during the local thermal action on stratum corneum. It is shown that the epidermal barrier permeability considerably increases under the island photothermal effect and application of various clearing agents. Detailed spectrophotometric investigations of skin under the conditions of a partial violation of the epidermis barrier functions due to the island effect and introduction of various immersion agents in the skin are presented. The effect of various conditions of the object illumination on the dynamics of spectra is analyzed. A common behavior of the dynamics of the spectra of all kinds during clearing is revealed. Possible mechanisms accompanying the optical clearing process under the island photothermal effect are discussed.
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